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Contraindications Contraindications are specific situations when medications should not be used
In animal experiments, GLP-1 has been shown to improve the metabolic efficiency of myocardial glucose, reduce systemic and pulmonary vascular resistance, and activate the ischemic preconditioning pathway ( Effect of GLP-1RAs on Inflammatory Response Induced by Sepsis In an observational study of patients with sepsis, it was found that endogenous GLP-1 was activated during sepsis, and GLP-1 levels were significantly elevated in patients with sepsis who died early (24 days post-admission) ( in vitro experiments of sepsis, GLP-1 analogs inhibited TNF and LPS-induced monocyte adhesion, thereby reducing vascular endothelial injury ( in vivo and in vitro (Young-Sun and Hee-Sook 2016)
FDA Approval: The FDA branded medications containing semaglutide and tirzepatide are approved for chronic weight management, while compounded formulations are not FDA-approved for this specific use
Risks and Considerations While effective, bariatric surgery involves risks such as infection, nutrient deficiencies, and the need for lifestyle adjustments
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