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Consistent with the view that remodeling is context dependent, therapy-induced senescence has been reported to increase MERCS' contact surface while reducing ER-mitochondria Ca2+ flux because of decreased IP3R expression and reduced IP3R1-VDAC1 interaction (235)
The potential for innovative formulations suggests a promising future for this class of drugs
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Some patients experience mild side effects such as nausea, bloating, or changes in bowel habits when starting GLP-1 therapy
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