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PC-SOD (recombinant human SOD1 covalently coupled to four molecules of lecithin) is a potent superoxide-radical scavenger with a 100-fold increase in protective effects against endothelial cell injuries, compared to unmodified SOD 567,568
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442 In addition, OPA1 lowering in the retina of diabetic mice also induced the expression of the pro-apoptotic gene Bax and the release of cytochrome c, which stimulated the apoptosis of retinal vascular cells
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