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1122 Autophagy-targeting chimeric molecules eliminate dysfunctional mitochondria, restoring mitochondrial function and ATP levels in Down syndrome fibroblasts, potentially preventing AD progression

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We, therefore, used alternative approaches and have determined the structure of a high molecular weight TrxR subfamily member using cryo-EM, demonstrating the feasibility of this methodology to study this protein subfamily of importance in several human diseases (PDB ID 8A1R, EMD-15084) (Fig