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These different directions of effect between metabolic health and motivational decision-making are not necessarily in competition: instead, our results could be explained by a positive feedback loop wherein decreased motivational tendencies and a behavioural bias towards energy conservation inhibits behaviours such as physical exercise, leading to weight gain and the continued maintenance or progression of metabolic dysfunction, which due to biological interactions between metabolic and neurocognitive mechanisms, also alter cognition and worsen motivational tendencies
You still enjoy eating, but it doesnt drive behavior in the same way. That mechanism has sparked interest far beyond obesity research
They are a natural byproduct of our bodies cellular processes
Intra-articular injection of C57Bl/6 mice with an adenovirus vector overexpressing active TGF- [86] or repeated in-articular injections of recombinant TGF- induced hyperplasia of synovium with increases in inflammatory immune cells, including macrophages [87]
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