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Alternative treatments should be considered by pregnant women, nursing mothers, and people with asthma, sulfite allergies, or specific kidney/liver conditions
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Because hydrophobic bile acids are harmful to hepatocytes and cholangiocytes, obstruction of bile flow causes retention of bile acids in the liver, resulting in liver damage ( Individuals with prolonged severe intrahepatic cholestasis (PSIC) have a higher mortality risk (44%) than patients without PSIC (20%) after orthotopic liver transplantation ( in vivo studies
Studies have progressed from initial in vitro observations to controlled clinical trials, particularly in the dermatological field
