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1) include (1) impaired chromosome integrity due to increased DNA damage (e.g., DNA double-strand breaks) [21], (2) weakened chromosome cohesion during chromosome segregation, causing a decrease in the level of chromosomal adhesin subunits, making oocytes susceptible to premature sister chromatid segregation in homologous chromosomes [22, 23], (3) dysfunction of spindle assembly checkpoints, which interferes with chromosome segregation, leading to premature chromosome segregation and chromosome mislocalisation [24], (4) meiotic recombination errors [25], and (5) telomere shortening leading to impaired chromosome integrity [25]

Since then, there was a definite shift in the medical community where researchers were looking for a safer way to boost HGH levels

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