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Results: Oral semaglutide reduced HbA1c levels compared to placebo Oral semaglutide patients experienced significant weight loss compared to those on placebo The primary outcome (composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) occurred in 3.8% of patients in the oral semaglutide group and 4.8% in the placebo group, which showed that cardiovascular safety of oral semaglutide was non-inferior to placebo

Probabilities varied substantially depending on the dose combination under the primary equivalence margin ( 2 percentage points)

Obesity classification as a chronic disease requiring ongoing pharmaceutical intervention remains a recent shift in medical policy, and many insurers have not updated their coverage criteria accordingly

Analyst Olivia Brayer found the data, which were previously unreported, in hidden tabs of a file attached to a Nature Metabolism publication of early trial results for MariTide