Body weight did not change significantly and all DPP-4 inhibitors were well-tolerated
Administration is straightforward: subcutaneous injection with an insulin needle, once daily, self-administered at home
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Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]