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In T2DM patients at high risk for cardiovascular events in the LEADER clinical trial, those who received the GLP-1 RA liraglutide experienced fewer events in the primary composite outcome (the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) than the placebo group, with a median follow-up of 42 months

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Retatrutide, with its additional glucagon pathway, may theoretically have different tolerance characteristics

Its about tuning into your body rather than overpowering it. The pair discuss how microdosing might be a bridge between lifestyle and medication allowing people to pair science-backed pharmaceuticals with nutrition, movement, and gut health practices that reinforce metabolic balance