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In other cells, various signaling cascades, including activation of MAPK, phospho-inositol-3-phosphate kinase (PI3K), adenylate cyclase and PKC by GLP-1 agonists, mediate the effects of GLP-1R activation on various cellular functions including insulin secretion and biosynthesis, -cell proliferation and neogenesis
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GLP-1GIPLani also suppressed endogenous glucose production with greater efficacy than GLP-1GIP (Fig
