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Results from clinical trials suggest that such drugs could have potential for the treatment of asthma, which is one of the most chronic inflammatory pulmonary diseases in the world and often linked to both type 2 diabetes and obesity (Wu, Stokes Peebles)
All four of these inhibitors reduce the reabsorption of filtered glucose, decrease the renal threshold for glucose, and promote urinary glucose excretion. Studies show that SGLT-2 use in diabetic kidney transplant recipients resulted in a decrease in hemoglobin A1C. There were potential side effects including increased infection risk and fluctuating allograft function
The beneficial effects of estrogens and GLP-1 agonists observed in other metabolic diseases raise the possibility that their combined use could also prevent or delay the onset of Alzheimers disease
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