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The Food and Drug Administration (FDA) has approved both drugs for weight management in adults with: a body mass index (BMI) of 30 or higher (obesity) a BMI of 27 or higher (overweight) plus at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol Wegovy also has the following approved uses: Cardiovascular health: Wegovy is approved to reduce the risk of major heart-related events like heart attack or stroke in adults with known heart disease who have obesity or are overweight
Nature 396 , 329335 (1998)
Central injection of AgRP has a potent stimulatory effect on food intake which can also be seen using a MC4R antagonist
& Baler, R
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