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Author contributions HL conceived the study
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Mechanistically, this relationship is driven by chronic low-grade inflammation, insulin resistance, increased levels of insulin and IGF-1, elevated estrogen and adipokines such as leptin, and impaired immune surveillance, all of which contribute to tumor initiation, proliferation, and evasion of apoptosis [144]
There are also theoretical concerns regarding heart rate elevation , as observed with other agents in this class
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