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Both medications may be considered for individuals with obesity or who are overweight with at least one weight-related condition, such as high blood pressure, high cholesterol, or Type 2 diabetes

Generally, incretin hormones such as GLP-1 and GIP are released from intestinal L-cells and play an essential role in physiologically mediating insulin secretion after a meal [14]

Exendin-4 exposure also led to a significant reduction in the level of reactive oxygen species (ROS) in Control shRNA islets exposed to the ER stress drug thapsigargin, but this effect was no longer present in SPHKAP shRNA-transduced islets, which presented with generally higher ROS levels than the corresponding control islets (Fig

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