transitioning from tirzepatide to semaglutide Switching between weight-loss medications Early Dose Escalation of Tirzepatide

(1) Participants: adult patients (aged 1880 years) with the similar duration of obesity and with a newly diagnosed T2DM, pharmacologically naive, with a similar state of metabolic balance (similar HbA1c level), not achieving weight loss during previous (at least one year) non-pharmacological treatment for obesity (2) ability to give informed consent, understand and comply with the study procedures

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Patients with kidney issues should be closely monitored

Factors such as baseline metabolic status, adherence to lifestyle modifications, and dose escalation schedule all influence the timeline