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In the 1980s, research was active, but interest subsequently declined

No concerns

DO NOT USE if you have: Active cancer or history of cancer (IGF-1 promotes cell proliferation) Diabetic retinopathy or other proliferative retinopathies Poorly controlled diabetes Significant cardiovascular disease DO NOT USE if you are: Under 25 years old with open growth plates (risk of disproportionate growth) Unwilling to manage nutrition and blood sugar carefully Unable to source legitimate, tested product from a reliable supplier The black market is flooded with underdosed, mislabeled, or completely fake IGF-1 DES. For all you know, you could be injecting anything into your body

Hepatology 49:13751384