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If significant deficiency is confirmed via blood test, a loading dose protocol may be recommended in line with NICE guidance typically more frequent injections over the initial weeks to rapidly restore levels

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In the study above, the authors note that more drugs [from postauricular injection] concentrated in the inner ear for longer therapeutic time, and less systemic delivery implied less risk of side effects. Practical Considerations: Injection Scheduling Protocol typically involves multiple injections over 12 weeks

doi: 10.4103/1450-1147.176882 281 De WeverWCeyssensSMortelmansLStroobantsSMarchalGBogaertJet al