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In cases where TFF alone doesnt achieve the required concentration, operators may leverage thin film evaporation, which further concentrates the solution while minimizing its exposure to heat
Benoist 2014, PMID 25187433, retraction notice PMID 40312093), and a third carries a 2021 Expression of Concern (McCoy 2013, PMID 23055539)
For semaglutide specifically, treatment should be discontinued at least 2 months before a planned pregnancy
Some patients may benefit from transitioning to lower doses of GLP-1 medications rather than complete discontinuation, though this approach requires further research to establish optimal dosing strategies
