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Shepard, D
In a randomized, placebo-controlled trial in 1,374 participants who had colonoscopic removal of at least one colorectal adenoma (the Selenium and Celecoxib trial), selenium supplementation (200 g/day with selenized yeast) for a median of 33 months had no effect on colorectal adenoma recurrence (88)
In the face of vitamin B 12 deficiency, conversion of methylmalonyl-CoA to succinyl-CoA cannot take place, which results in accumulation of methylmalonyl-CoA and aberrant fatty acid synthesis
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