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Knowing how to manage them can help you stay comfortable and adherent to treatment: For nausea and digestive discomfort: Eat smaller, more frequent meals Limit ultra-processed foods and takeaways Stay well hydrated (2-3 litres a day) Consider ginger tea or supplements (shown to help in clinical settings) Avoid lying down immediately after eating For fatigue: Ensure adequate protein intake Maintain electrolyte balance by eating a diet based on whole foods (supplements not necessary unless prescribed) Prioritise 7-8 hours of sleep Consider timing your injection before bed if daytime fatigue is significant In clinical trials, approximately 65% of participants experienced at least one side effect during the first month, but this dropped significantly by month three as the body adjusted 1

Tirzepatide slows gastric emptyingthe rate at which your stomach moves food into your small intestineso taking it when your digestive system is already processing a heavy meal may amplify initial side effects

28 Interestingly a study published by the Mayo Clinic 29 reported seemingly opposite findings, showing a protective cardiac effect for carnitine in some patients

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