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Risk factors that might warrant consideration of medication adjustment include: Recent initiation or dose escalation of GLP-1 therapy Significant gastrointestinal symptoms (nausea, vomiting, early satiety) Maximum medication doses Known gastroparesis or other conditions affecting gastric emptying For patients where holding the medication is deemed appropriate, the duration should be individualized based on the specific medication, patient factors, and clinical judgment

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2 Natural bioactive as multitarget therapeutics in metabolic and liver disorders Naturally occurring flavonoids help manage type 2 diabetes by modulating key glucose-metabolizing enzymes