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1 Also known as the ominous octet, the pathophysiology of T2DM has been recognized as much more complex, impacting not only the pancreas but also the muscle, liver, adipocytes, gastrointestinal tract, alpha-cells, kidney, and brain

It remains available only as a research compound

Despite the consensus on the role of genetic predisposition and the greater susceptibility of vitiligo development, in monozygotic twins, vitiligo develops in only 23% of both twins (Alkhateeb et al., 2003), suggesting that the environment can induce or suppress the genes related to vitiligo development via DNA methylation, histone modifications and alteration of circulating microRNA (Zhou et al., 2019)