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For the EdU assay, AGS cells were seeded into 6-well plates, treated as indicated, and incubated with 50 M EdU (YEASEN, YF594 Click-iT EdU Imaging Kit) for 2 h
However, if the purpose of the drug is to be taken up by the liver, then first-pass metabolism may be irrelevant (the drug is still metabolized into hepatic glutathione, which is what matters)
For instance, Novo Nordisk, the manufacturer of Ozempic and Wegovy, offers a Drug Disposal Program where consumers can order sharps disposal containers or medicine return containers directly from their website, along with return shipping directions
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