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Dysfunction of cystinosin results in the intralysosomal accumulation of the disulfide cystine, which crystallizes in some tissues and damages many parenchymal organs

Trimethylamine-N-oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway

Adenosine has multiple physiological effects both within the central nervous system and on peripheral tissues that are mediated by the G-protein coupled adenosine receptors identified as A 1 , A 2A , A 2B , and A 3

We sought to determine whether the maintained adaptive level was sufficient to prevent CS induced GSH depletion upon repeated CS exposures