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The balance between pro-inflammatory M1 and anti-inflammatory M2 macrophages is a critical determinant of antitumor immunity, and the dominance of M2-polarized TAMs in osteosarcoma correlates with poor prognosis and resistance to immune-based therapies (9, 28)
Ocular Symptoms 1 Significant and clinically meaningful improvements in rTOSS with Ryaltris vs placebo on each of the 14 study days
Cooper AJL
Treatment began when tumors reached ~100 mm, with mice randomized to vehicle, APR-017(100 mg/kg per day, ip
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