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Some of these reported injuries have required emergency medical intervention and, in extreme cases, have resulted in permanent lifestyle changes

Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue

[10] [11] More recently, the SELECT trial showed that Wegovy significantly reduced the risk of major adverse cardiovascular events in adults with established cardiovascular disease and overweight or obesity without diabetes, leading to an FDA-approved cardiovascular risk reduction indication

Clinical trials track predefined adverse events with strict reporting criteria