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The SURMOUNT-1 DXA substudy (Look et al., 2025) showed that tirzepatide reduced lean body mass by 10.9% over 72 weeks, compared to 2.6% with placebo

IGF-1R Binding and Downstream Signalling IGF-1 LR3 remains a full agonist of the IGF-1 receptor, with very low affinity for IGFBPs making it more potent than unmodified IGF-1 in cell culture and pre-clinical models

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