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Practical Considerations for Starting Combined TRT and GLP-1 Therapy If you are already on stable TRT, adding a GLP-1 medication typically requires no adjustment to testosterone dosing
Mazzone SB, Undem BJ
Retatrutide (LY-3437943) is an investigational drug developed by Eli Lilly that acts as a triple hormone receptor agonist : GLP-1 (glucagon-like peptide-1) receptor agonist GIP (glucose-dependent insulinotropic polypeptide) receptor agonist Glucagon receptor agonist - read about why this is so important here This triagonist approach amplifies the metabolic impact seen with GLP-1 and GIP combinations like tirzepatide, while also leveraging glucagons thermogenic and energy-expending properties
Ruiz-Pozo et al., 2023) The PI3K/Akt pathway is also responsible for regulating protein clearance systems like autophagy and the ubiquitin-proteasome system
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