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Disrupted lipid metabolism induces mitochondrial FAO inhibition, excessive inflammation, and ROS overproduction, thus leading to the pathogenesis of various pulmonary diseases

Poljsak B et al

COVID-19 and toll-like receptor 4 (TLR4): SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation