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Its receptors, found in the pancreas, stomach, kidney, heart, lungs, skin, immune cells, and hypothalamus, stimulate insulin release, slow stomach emptying, inhibit post-meal glucagon release, and reduce food intake

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Orforglipron redujo la hemoglobina glicosilada (HbA1c) en un 1,9% (12 mg) y un 2,2% (36 mg) de media, en comparacin con un 1,1% (7 mg) y un 1,4% (14 mg) con semaglutida oral a las 52 semanas, lo que supone una reduccin relativa un 57,1% mayor en la comparacin de las dosis ms altas