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Carnitine-acyltransferase system inhibition, cancer cell death, and prevention of Myc-induced lymphomagenesis

The relatively positive safety profile of many peptide drugs may indeed be related to the use of smaller peptides, unnatural amino acids, and cyclized peptides, contributing to a lack of HLA-binding sequences (a prerequisite for immunogenicity)

Cluster-3 consisting of N- linker-2-chloroacetamides was mostly inactive, suggesting that inclusion of additional linker groups between the chloroacetamide moiety and the aromatic centre decreased its electrophilic nature and negatively affected potency

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