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In mouse primary chondrocytes stimulated with IL-1, liraglutide treatment downregulated Tnf and nitric oxide synthase 2 (Nos2)
What This Study Teaches Us The review suggests cannabinoids, acting through CB1- and CB2-receptor-mediated pathways in the endocannabinoid system, may produce modest, patient-reported symptom benefits beyond pain, including reduced spasticity in multiple sclerosis, fewer seizures in treatment-resistant pediatric epileptic syndromes, antiemetic effects in refractory chemotherapy-induced nausea and vomiting, and appetite stimulation in cachectic states
Decades of clinical trials support its efficacy for weight loss and glycemic control
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