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This proportion can vary considerably depending on several factors: Rate of weight loss : Rapid weight loss tends to result in greater proportional lean mass loss Baseline body composition : Individuals with lower initial fat mass may lose proportionally more lean tissue Protein intake : Inadequate dietary protein increases muscle protein breakdown Physical activity levels : Resistance training and adequate physical activity help preserve muscle mass Age : Older adults are more susceptible to muscle loss during weight reduction The concern with GLP-1 medications centres on whether they cause disproportionate muscle loss compared to other weight loss methods

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However, refrigerating between injections preserves stability and may improve tolerability