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Small prospective trials of diabetic patients with GLP-1 RAs have shown benefits in improved lung function in non-asthmatic patients and reduction in exacerbations in patients with asthma
Mechanistic Insight Interestingly, only ~52% of the improvement in insulin resistance (HOMA2-IR) appears attributable to weight loss, pointing toward an additional GIP-mediated metabolic effect with tirzepatide
Jumping straight to a high Wegovy dose risks severe side effects
Fatigue is specifically listed as a common adverse reaction (occurring in 5% of patients) in Wegovy clinical trials, though it is less prominently featured in Ozempic labeling
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