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Reading the Numbers Honestly: The Full Comparison Table With the cross-trial caveat firmly established, the attribute-by-attribute comparison below summarises what is documented for each compound
We focus on structural design and formulation integrity rather than chemical permeation enhancers
Limited clinical validation: Despite decades of research interest, DSIP has not progressed into wide-scale clinical adoption, which raises questions about consistency and reproducibility of effects
N Engl J Med 2021;384:989-1002
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