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In the SURMOUNT-1 trial involving participants without diabetes, those receiving the highest dose (15 mg weekly) achieved an average weight loss of 20.9% from baseline at 72 weeks, compared to 3.1% with placebo
Semaglutide is a medication initially developed to manage type 2 diabetes, but it has also proven to be highly effective for weight loss
Its best practice to draw each dose from the vial immediately before use
The mechanism likely involved is that catalpol inhibits H 2 O 2 -induced ROS, MDA, Bax, and caspase-9 production while activating SOD, GSH-Px, and Bcl-2 expression (Yan et al., 2020)
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