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10.1038/s41598-019-46391-6 25 McKennaZ
Secretagogue-induced release (CJC-1295/Ipamorelin): GH released in pulses, with peak amplitude during sleep-associated secretory windows Ipamorelin induces an acute GH pulse within 15-30 minutes of administration CJC-1295 (No DAC) extends GH elevation for approximately 30 minutes per pulse Combined administration produces amplified pulses documented in Bowers et al
A small subset of patients may experience appetite rebound during the washout period between stopping semaglutide and starting tirzepatide
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