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Supplementary information Additional methods and analysis details

In these trials, test subjects receiving melanotan I had 47% fewer sunburn cells on their neck and significantly enhanced tanning on their back compared with the control group [4]

PMID: 22708999.

Notably, mitochondrial dysfunction is closely linked to NLRP3 inflammasome activationbone marrow-derived macrophages deficient in Lcn2 exhibit reduced mitochondrial damage, accompanied by diminished NLRP3 activation and decreased IL-1 production [126]