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When GCDH is knocked down in melanoma cells, it leads to increased glutarylation of NRF2, a transcription factor that becomes stabilized and transcriptionally active

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The bifurcated nature of current litigation (with gastrointestinal claims proceeding federally and vision loss claims advancing through state courts) creates pressure on manufacturers from multiple directions simultaneously, increasing the likelihood that Novo Nordisk and Eli Lilly will eventually pursue comprehensive settlement frameworks addressing both injury types