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Recent studies have shown that increased ROS production promotes reversible uncoupling of NO synthase (NOS) and shifting the enzyme activity to produce more ROS instead of NO [51], [52]
Melanotan-II (MT-II), a synthetic peptide known to mimic alpha-melanocyte-stimulating hormone (-MSH) and act as a melanocortin receptor 4 (MC4R) agonist, was the central therapeutic agent explored
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