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"When women are losing weight, they're satisfied, and some people are willing to go through the stomach pain, the throwing up, the fatigue," and worse, Hirston says

Discontinue use if signs of hypersensitivity, such as rash or anaphylaxis, occur

At the same time, there is evidence of T cell exhaustion and reduced natural killer cell function, suggesting the immune system is simultaneously overactivated in some pathways and depleted in others