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Thus, although the increase in CNS-GLP-1R signaling is sufficient to activate BAT thermogenesis, whether this regulation is necessary for the contribution of BAT thermogenesis to the control of energy balance, or to the body weight lowering effects of GLP-1 based therapies still requires further investigation

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Why "fat burner" framing doesn't hold up An accurate fat-loss tool typically influences at least one of these directly: Appetite and satiety regulation Energy expenditure/thermogenesis Lipolysis and fat oxidation pathways Glucose regulation in a clinically meaningful way BPC-157 has not been established as reliably effective in humans for those categories of fat loss

2007;293:G104653