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Early treatment phases typically start patients at lower unit amounts (2.4 units or 0.2 mg) and increase gradually every 4 weeks to allow the body to adjust and minimize nausea
Retatrutide for non-diabetic weight loss is a new drug tested to assist in weight loss among individuals without diabetes
For instance, in November 2023, results from the SELECT trial published in the New England Journal of Medicine showed that once-weekly semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease without diabetes, highlighting the expanding role of long-acting GLP-1 analogues beyond glycemic control into cardiovascular risk reduction
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