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Broader endocrine rewiring, including modulation of biomarkers linked to adipose regulation and insulin sensitivity, further underscores its potential in metabolic syndrome and cardiovascular risk research

second-generation clocks that predict mortality/morbidity risk (PhenoAge and GrimAge, including a principal-component version of GrimAge denoted PCGrimAge)

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Cell apoptosis was quantified via Annexin V-FITC/PI staining followed by flow cytometric analysis, differentiating early and late apoptotic cells