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The pentose phosphate pathway can also function as an anabolic pathway that utilizes the six carbons of glucose to generate five carbon sugars, particularly ribose-5-phosphate (R5P) that is required for purine and pyrimidine nucleotide biosynthesis
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(2000) reported the example of the monogenic disease, Immunodeficiency, Centromeric instability and Facial anomalies (ICF) syndrome, which is a Mendelian disorder associated with DNMT3B mutations and DNA methylation defects of satellite and non-satellite regions (Hobbs et al., 2000)
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