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5.1.14 Arbutin Arbutin is an organic glucopyranoside that can inhibit tyrosinase activity and avoid melanocyte maturation without the risk of toxic effects

A total of 75 islets were loaded into individual chambers and perifused at a constant rate of 200 l min 1 using 2.7 mM glucose Krebs-Ringer-phosphate-HEPES (KRPH) buffer (140 mM NaCl, 4.7 mM KCl, 1.5 mM CaCl 2 , 1 mM NaH 2 PO 4 , 1 mM MgSO 4 , 2 mM NaHCO 3 , 5 mM HEPES and 0.1% FA-free BSA (pH 7.4)) with 100 l of Bio-Gel P-4 Media (Bio-Rad)

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This suggests that the reduction in blood pressure could be a direct effect of the GLP-1 mimetic