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The permanent schedule-change protocol If you need to move your injection day permanently (Friday to Thursday, for example), the safe protocol depends on which direction you're moving: Moving to an earlier day in the week (Friday to Thursday): Option 1: Gradual transition Week 1: Take your Friday dose as scheduled Week 2: Take your dose on Thursday (one day early, within safe window) Week 3 onward: Continue Thursday schedule Option 2: Gap transition (more conservative) Week 1: Take your Friday dose as scheduled Week 2: Skip the dose entirely Week 3: Begin Thursday schedule This creates an 8-day gap once, avoiding any dose stacking Moving to a later day in the week (Friday to Saturday): Week 1: Take your Friday dose as scheduled Week 2: Take your dose on Saturday (one day late, safe) Week 3 onward: Continue Saturday schedule Moving to a later day is simpler because you're creating a gap, not compressing doses

these changes showed up by week 3 and held at 2 months

When to seek urgent medical attention : Contact your GP or seek emergency care if you experience: Severe, persistent abdominal pain (possible pancreatitis) Right upper quadrant pain, fever, or jaundice (possible gallbladder disease) Sudden vision changes or eye pain (possible acute glaucoma) Signs of severe dehydration (dizziness, reduced urination, confusion) Suicidal thoughts or severe mood changes Symptoms of metabolic acidosis (rapid breathing, confusion, fatigue) Severe allergic reactions (rash, swelling, difficulty breathing) If you experience any suspected side effects, you can report them through the MHRA Yellow Card scheme

The single-cell RNA sequencing data presented in the main figures has been deposited at the Broad Institute Single Cell Portal and are accessible at the following URL: [ The dataset reported in our previous study (Zhao et al.) is accessible at the following URL: [ All other data are available from the corresponding authors upon reasonable request