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This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured
Although some of these drugs have been prescribed since 2017, their popularity seems to have exploded in the last year, thanks to their use by celebrities, earning them the nickname the Hollywood drug. The social media visibility of these drugs and their remarkable effects on weight loss has led to demand far greater than supply, leading to shortages and an obsession with accessing these precious injections
doi: 10.1007/s00125-023-05988-3 20 JolivaltCGFinemanMDeaconCFCarrRDCalcuttNA
The reconstituted solution might look cloudy or have visible particulates floating in it
