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Dosage and Frequency Once a week Taken on the same day each week, any time of day, with or without food

The peptide consists of 29 amino acids with four key substitutions compared to natural GHRH: position 2 (D-Ala instead of Ala), position 8 (Gln instead of Ala), position 15 (Leu instead of Ala), and position 27 (Ala instead of Leu)

In a 26-week phase 2 trial involving individuals without diabetes, it was evaluated at doses ranging from 0.3 mg to 4.5 mg per week

After the clinical observation of phenotypes attributable to PFIC, current research techniques enable the isolation of novel variants related to known genes or variants in other genes that determine known or new cholestatic intrahepatic phenotypes